The effectiveness of current treatments for COVID-19 virus variants is a topic of concern. Vaccines, antiviral drugs, and monoclonal antibodies are among the treatments being used. While vaccines have proven effective in preventing severe illness, their effectiveness can vary depending on the variant targeted. Antiviral drugs have shown potential in reducing symptom severity, but their effectiveness against different variants is not yet clear. Monoclonal antibodies have shown promise in treating mild cases, but their effectiveness against variants is still unknown. Ongoing monitoring of treatment effectiveness against emerging variants is crucial for better protection against the disease.